http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2000502675-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4409 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-30 |
| filingDate | 1996-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2000-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2000502675-A |
| titleOfInvention | Tri-substituted phenyl derivatives useful as PDE IV inhibitors |
| abstract | (57) [Summary] A compound of the general formula (1) (wherein = W- is (1) = C (Y)-[Y is a halogen atom, alkyl or -XR a group, and X is -O-, -S (O p ) (p is zero, an integer having a value of 1 or 2), or -N ( Rb )-( Rb is a hydrogen atom or an optionally substituted alkyl group), and Ra is A hydrogen atom or an optionally substituted alkyl group] or (2) = N-; L is -XR (R is an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group ), -C (R 11 ) = C (R 1 ) (R 2 ) or [-CH (R 11 )] n CH (R 1 ) (R 2 ) group, wherein R 11 is a hydrogen atom , A fluorine atom or a methyl group, R 1 and R 2 may be the same or different, and each is a hydrogen atom, a fluorine atom or an optionally substituted alkyl, alkenyl, alkynyl, alkoxy, alkylthio, -CO 2 R 8 ( R 8 is a hydrogen atom or an optionally is substituted Alkyl, aralkyl or aryl group), - CONR 9 R 10 ( R 9 and R 10 may be the same or different, is as defined R 8), - CSNR 9 R 10, -CN or - Is a NO 2 group, or R 1 and R 2 are joined together with the C atom to which they are attached to form an optionally substituted cycloalkyl or cycloalkenyl group, where n is zero or an integer of 1 R 3 is a hydrogen atom, a fluorine atom, an optionally substituted linear or branched alkyl group, or a hydroxyl group; the remaining groups are as defined in the specification), and Salts, solvates, hydrates, prodrugs and N-oxides have been described. The compounds of the present invention are type IV inhibitors of phosphodiesterases and are useful in the prevention and treatment of diseases such as asthma where an unwanted inflammatory response or muscle spasm is present. |
| priorityDate | 1995-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 251.