| abstract |
(57) Abstract: The present invention is directed to the treatment of diseases, including asthma, by inhibiting phosphodiesterase IV (PDEIV) and increasing the level of cyclic adenosine-3 ', 5'-monophosphate (cAMP). Useful formula (I): Of the novel compounds. The invention further encompasses certain pharmaceutical compositions and methods of treating disease by increasing cAMP by inhibiting PDE IV, including the use of compounds of formula (I). |