| abstract |
(57) An object of the present invention is to provide an excellent insulin sensitizer, 5-lipoxygenase inhibitor comprising a substituted condensed heterocyclic compound or a pharmaceutically acceptable salt thereof as an active ingredient. Provided are a lipid peroxide production inhibitor and the like. SOLUTION: The general formula: [In the above formula, R 1 is a general formula: (Wherein, R 4 : substituted phenyl group, optionally substituted pyridyl group; R 5 : hydrogen atom, etc .; R 6 : hydrogen atom, C 1 -C 6 alkyl group, etc .; D: oxygen atom, sulfur atom; E: C A group having H, a nitrogen atom); R 2 : a hydrogen atom and the like; R 3 : 2,4-dioxothiazolidine-5-ylmethyl group and the like; A: C 1 -C 6 alkylene group; B: oxygen atom, sulfur atom; However, 5- {4- [5- (3,5-di-t-butyl-4) -Hydroxyphenylthio) -3-methyl-3H-imidazo [4,5-b] pyridin-2-ylmethoxy] benzyl {thiazolidine-2,4-dione is excluded. ] Or a pharmacologically acceptable salt thereof as an active ingredient. |