| abstract |
(57) [Problem] To provide a preventive or therapeutic agent for tachykinin-mediated diseases. A prophylactic or therapeutic agent for tachykinin-mediated diseases, comprising a compound having the general formula (I) or a pharmaceutically acceptable salt or derivative thereof. : ｛R 1 : a replaceable cycloalkyl, a replaceable saturated heterocyclic group; R 2 : replaceable aryl, replaceable heteroaryl; A: methylene, carbonyl, sulfonyl; B: single bond, alkylene, alkenylene; D: oxygen atom, sulfur atom; G: alkylene, alkenylene; L: —N (R 3 ) —, —C (R 4 ) (R 5 ) — [R 3 : replaceable aryl, replaceable heteroaryl, R 4 : H, replaceable aryl, replaceable heteroaryl, replaceable cycloalkyl, replaceable heterocyclic ring R 5 : amino-substitutable alkyl, amino, substitutable acylamino, OH, substitutable hydroxyalkyl, alkoxy, —CO—R 6 (R 6 : alkyl, alkoxy, amine residue and the like); or R 4 and R 5 together form a cycloalkane ring, a cycloalkene ring and a saturated heterocyclic ring]; R 7 : alkyl; Z: two H, oxygen atoms; n: 0, 1, 2}. |