| abstract |
(57) [Summary] [PROBLEMS] Various diseases caused by changes in the activity of serine proteases, particularly plasmin, plasminogen activator and other serine proteases involved in the fibrinolytic system, especially skin diseases, rough skin of healthy individuals, Improvement of roughness, etc. Provided is a serine protease activity inhibitor having an excellent prevention effect. SOLUTION: Plants belonging to the family Rosaceae, in particular, the genus Rosaceae (Rosa), the genus Rubus (Rubus), the genus Spiraea (Filipendula), and the genus Hawthorn (Cra) taegus), which comprises one or more selected from plants belonging to the group of taegus) as an active ingredient. |