| abstract |
(57) Abstract: A novel estra-1,3,5 (10), 16-tetraene derivative or pharmacology which exhibits steroid sulfatase inhibitory activity and is useful for the treatment or prevention of hormone-dependent diseases. To provide chemically acceptable salts. SOLUTION: General formula (I) wherein R 1 is hydroxy, alkoxy or NR 2 R 3 (wherein, R 2 and R 3 are the same or different, hydrogen, a branched lower alkyl of straight chain lower alkyl or 3 to 8 carbon atoms having 1 to 3 carbon atoms) represented by the representative of the ' Provided is an estra-1,3,5 (10), 16-tetraene derivative or a pharmaceutically acceptable salt thereof. Embedded image |