| abstract |
(57) [Problem] To provide a medicine widely applicable to vomiting caused by a drug having an emetic action. SOLUTION: embedded image A heterocyclic ring having -CS-N <; R a and R b are bonded together to form a ring A, or the same or different and a substituent on a hydrogen atom or an M ring; A homocyclic or heterocyclic ring optionally having a group, at least one of which is a heterocyclic ring optionally having a substituent; C The ring is a homo- or heterocyclic ring which may have a substituent; the Z-ring is a nitrogen-containing heterocyclic ring which may be substituted; and n is an integer of 1 to 6. Or a salt thereof, and a drug having an emetic action. The compound (I) or a salt thereof is useful as an emetic suppressant, and can particularly rapidly suppress vomiting caused by a drug having an emetic action at a low dose and safely. |