| abstract |
(57) [Problem] To provide a method for efficiently producing tetrahydrofolic acid by a fermentation method and a microorganism which can be used in the method. SOLUTION: A microorganism having resistance to folate analogs such as trimethoprim or sulfaguanidine and having the ability to produce tetrahydrofolate is cultured in a medium, and tetrahydrofolate is produced and accumulated in the cells of the microorganism. Produce folic acid. |