| abstract |
(57) [Summary] [PROBLEMS] To prevent deterioration of the active ingredient pravastatin sodium in a tablet due to conversion into a lactone form. SOLUTION: Neutral to pH 9 as excipients for tablets A pravastatin sodium tablet is prepared by a conventional method using a substance that is less than. Preferably, a substance having a buffering or antacid action is used as part of the excipient. In addition, tablets obtained by tableting by a direct method based on mannitol not only can prevent changes to lactone bodies, Does not delay disintegration and elution times. |