| abstract |
(57) [Problem] To provide a compound excellent in a hair growth promoting effect, a hair growth effect, and a hair loss preventing effect, and a hair tonic and a skin external preparation containing the compound as an active ingredient. A (2-substituted oxyphenyl) alkaneamide derivative of the formula (I) and a salt thereof. Also, a hair nourishing agent and a skin external preparation containing this as an active ingredient. Embedded image (One of A and B is a C 3-30 hydrocarbon group R 1 , and the other is- (C H 2 ) n -NR 2 R 3 ; Z is -CO-, -CONR 6- ; R 2 , R 3 is H, lower alkyl, benzyl, or R 2, but R 3 form a heterocyclic ring of 3-7 membered together, -CONR 5 - (CH 2) n-NR 2 R 3 , -CONR 6 - (CH 2) n-NR 2 R 3 may be a group of formula (II). Embedded image (Ring Y is a 6- to 7-membered heterocycle); R 4 is H, halogen, lower alkyl, etc .; R 5 and R 6 are H, lower alkyl, lower acyl, etc .; l is 0.1; m = 1,2 N is an integer from 0 to 5; ) |