| abstract |
(57) [Summary] Human relA binding inhibitor (RAI) consisting of 351 amino acids and a method for producing the same, cDNA encoding the RelA binding inhibitor, a fragment selectively hybridizing to the cDNA sequence, Its cDN A replication or expression plasmid incorporating A, a host cell transformed with the plasmid, an antibody of the polypeptide, a pharmaceutical composition containing the peptide or antibody, A method for diagnosing a disease using the RAI antibody. [Effect] The RAI of the present invention binds to p65 which is a subunit of NFκB, and is considered to be related to NFκB. ), Ischemic diseases, autoimmune diseases including rheumatoid arthritis, metastatic invasion of cancer, vascular restenosis, and other diseases involving NFκB, etc., are considered to be useful for treatment and / or prevention. |