http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2000210078-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_522d2abd01b2bf1c6b411c93f34f6dd4 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 |
| filingDate | 1999-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c66aefcb85a76e2a57923485e59d5e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74382b026946531d6e13ec192dbea6f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_244519b1a7c691348a2b767df47a9460 |
| publicationDate | 2000-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2000210078-A |
| titleOfInvention | Animal cell line in which prion gene is modified to be non-functional and its use |
| abstract | (57) [Problem] To provide a method for removing a prion disease pathogen from a virus vaccine and a method for detecting an abnormal prion gene in a mammal. SOLUTION: A mammalian cell line which is grown in a serum-containing medium but undergoes apoptosis in a serum-free medium, has a prion gene deleted or is mutated to be non-functional, and this cell line is cultured. A method for propagating a virus for vaccines comprising recovering a virus that has been infected and propagated with a virus for vaccines, and an anti-viral vaccine comprising attenuating or inactivating the virus as necessary and mixing with a pharmaceutically acceptable carrier. A method for producing, and a method for detecting an abnormal mammalian prion gene based on apoptosis or proliferation by culturing a transformant obtained by introducing the prion gene into the above-described cell line in a serum-free medium. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006320289-A |
| priorityDate | 1999-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 106.