| abstract |
(57) [Summary] [Problem] A novel preventive / treatment improving agent for psychiatric disorders, for example, a preventive / treatment improving agent for schizophrenia, depression, anxiety, senile dementia of Alzheimer's type, cerebrovascular dementia, chronic depression of stroke And a preventive / ameliorating agent for a disease effective in inhibiting glutamate uptake. SOLUTION: A phenylpyrrolidinone derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof. Embedded image R 3 represents a group represented by the following general formula, and ring Z represents a benzene ring, a pyridine ring or a cyclohexane ring. Embedded image R 1 , R 2 , R 4 and R 5 represent a substituent. p is 0 or 1-5 And m represents 0, 1 or 2. A is a group represented by the formula —NH— or a group represented by the formula — (CH 2 ) q— (q is 0 or 1 Means an integer of ~ 6. ). |