| abstract |
PROBLEM TO BE SOLVED: To provide a pharmacologically effective compound which can regulate blood pressure by giving a complete but suppressed range of physiological responses. hyperactivity, with diuretic and / or vasodilator activity, wherein Z 1 -AA 8 -AA 9 -AA 10 -AA 11 -AA 12 - Peptide compound Z 2 [wherein, AA 8 and AA 11 are each independently a basic / non-cyclic or neutral / nonpolar / small or neutral / polar / non-cyclic amino acid residue, AA 9 And AA 12 are each independently neutral / nonpolar / in the D- or L-configuration. AA 10 is an acidic amino acid residue, and such a peptide compound is selected from the group consisting of: 1) Z 1 has the predetermined formula Y 1 -Y 2 And Z 2 is N A compound such as H 2 , NHR ′ or NR′R ″, or a peptide residue of 1 to 20 amino acid residues, and 2) Z 1 and Z 2 together form a bridge and Z 1 Has the formula X 1 -AA 4 -X 2 , and Z 2 has the formula X 3- Compound having AA 20 -X 4 ]. |