| abstract |
(57) [Summary] [Problem] Na- has a preventive and therapeutic effect on ischemic heart disease and the like. An H exchange inhibitor is provided. SOLUTION: The formula: [In the formula, ring A is a 5- or 6-membered aromatic heterocyclic ring which may be substituted, and ring B is 5 or 6 which may be substituted. R 1 represents a hydrogen atom, a hydroxyl group or a lower alkyl group, and n represents 0 or 1. Or a salt thereof. The Na-H exchange inhibitor containing the above aminoguanidine hydrazone derivative is useful as a preventive or therapeutic agent for ischemic heart diseases such as myocardial infarction and arrhythmia. |