| abstract |
(57) [Problem] To provide a novel piperidine compound for treating human depression and other diseases of the central nervous system. SOLUTION: General formula (I): Is a novel 4-substituted piperidine. Wherein R 1 and R 2 are an unsubstituted aryl group or one or more halogen, alkyl, alkoxy, cyano, trifluoromethoxy, trifluoromethyl, benzoyl, phenyl, nitro, amino, aminoalkyl , Aminoaryl, or carbonylamino substituted aryl group. These are obtained as racemic mixtures and as pure enantiomers. These compounds and their pharmaceutically acceptable salts inhibit serotonin and / or noradrenaline reabsorption and are useful as antidepressants. Other promising therapeutic applications of these compounds include nervous overeating, obsessive-compulsive disorder, It is a prophylactic or therapeutic agent for drinking habits, anxiety, panic, pain, premenstrual neurosis, social phobia, and / or migraine. |