| abstract |
(57) [Problem] To provide a novel anti-edema agent, an edema formation inhibitor, and a blood-brain barrier vascular hyperpermeability inhibitor having low side effects and high safety. The present invention provides a novel anti-edema agent, an agent for suppressing edema formation and an agent for suppressing blood-brain barrier vascular hyperpermeability, which contain histamine-added immunoglobulin as an active ingredient. The pharmaceutical composition of the present invention suppresses the increase in vascular permeability of the blood-brain barrier and suppresses edema formation. It is known that histamine-added immunoglobulin which is an active ingredient of the pharmaceutical composition of the present invention has a low frequency of occurrence of side effects. Therefore, the pharmaceutical composition of the present invention is a highly safe novel anti-edema agent, edema formation inhibitor and It is useful as a blood-brain barrier vascular hyperpermeability inhibitor. |