| abstract |
(57) [Summary] (Corrected) [PROBLEMS] To find a protein that plays a major role in the long-term survival of brain nerve cells and a DNA encoding the protein. SOLUTION: The following properties: (1) a membrane protein; (2) Hydropathy analysis by the Kyte-Doolittle method has a structure characteristic of an interleukin receptor including a transmembrane part (once). (3) Strong expression is observed in the human adult brain, Of 10 %, But not expressed in other organs or human fetuses. (4) Overexpression in cultured undifferentiated human neurons induces cell death. (5) Excessive expression in cultured human normal cells. When induced, induces aging and mitotic arrest, And (6) a human-derived Bradion protein or an analogue thereof, specifically expressed in a human colon cancer cell line and a human skin cancer cell line, an antibody thereto, an antibody encoding the same, or a DNA encoding the same Use of fragments. |