| abstract |
(57) [Problem] To provide a compound having an excellent neuronal necrosis inhibitory action and useful as a therapeutic agent for cerebrovascular disorders. The following general formula [I]: Or a salt thereof, or a solvate thereof. In the formula, R 1 represents an aryl or an aromatic heterocyclic group. R 2 is hydrogen, alkyl, alkenyl, cycloalkyl, Represents cycloalkylalkyl, hydroxyalkyl, haloalkyl, alkoxy, alkylthio, amino, monoalkylamino, dialkylamino, or phenyl. R 3 and R 4 represent hydrogen or alkyl, or R 3 and R 4 4 together with an adjacent N represents NR 3 R 4 and represents a 5- to 7-membered cyclic amino. A represents an alkylene having 4 to 10 carbon atoms. E represents O or S. W represents a bond, O, S, or (CH 2 ) n (where CH 2 may be substituted by alkyl; n represents 0, 1 or 2). X, Y and Z are the same or different and represent CH (H may be substituted by alkyl) and N. Where X, Y, Except when Z is CH at the same time. The compound of the present invention has an excellent inhibitory action on neuronal necrosis, and is useful as a therapeutic agent for cerebrovascular disorders. |