| abstract |
PROBLEM TO BE SOLVED: To provide a method for producing a fluorine-containing benzyl alcohol derivative which is useful as a synthetic intermediate for pharmaceuticals, agricultural chemicals and the like in high purity and high yield. SOLUTION: Fluorine-containing benzonitrile derivative (formula 1) Is subjected to a reduction reaction to give a fluorine-containing benzylamine derivative (formula 2), and then the amino group of the fluorine-containing benzylamine derivative is replaced with a hydroxyl group to give a fluorine-containing benzyl alcohol derivative (formula 3). However, X in the formula is a halogen atom, and when m is 2 or more, Xs may be the same or different. m is an integer of 0-4. Embedded image |