| abstract |
(57) [Problem] To provide a purine derivative showing a remarkable therapeutic effect on liver disease without showing any serious side effects. SOLUTION: A purine derivative represented by the following general formula (2) or a pharmacologically acceptable salt thereof: [R 20 is - (CH 2) a m -R 60, R 60 represents a hydrogen atom, an alkyl group, an alkoxy group, a substituted aryl group, a substituted heterocyclic group, m represents 1 to 6; R 30 Represents a fluorine atom or a trifluoromethyl group; R 40 represents a hydrogen atom, Represents an alkyl group; R 50 represents an aryl group having a specific substituent; a heterocyclic group having a specific substituent; L 10 , L 20 represents a single bond or an alkylene group; provided that, when R 20 is a methyl group and R 30 is a trifluoromethyl group, the aryl group of R 50 has a specific substituent] or a similar compound thereof. For treating liver disease. |