| abstract |
[PROBLEMS] To provide a pharmaceutical composition containing an isoquinolinone derivative having an excellent PDE V inhibitory activity as an active ingredient. SOLUTION: General formula [I] (Wherein ring A and ring B are the same or different and are substituted or unsubstituted benzene rings, R 1 is (1) a hydrogen atom, (2) Substituted or unsubstituted lower alkyl group, (3) substituted or unsubstituted cyclo lower alkyl group, (4) substituted or unsubstituted aryl group, (5) substituted or unsubstituted heterocyclic group, or (6) mono- or di-substituted An optionally substituted amino group, R 2 has the formula: —COOR 3 or the formula: —CON (R 4 ) a group represented by (R 5 ), wherein R 3 is a hydrogen atom or an ester residue, and a group represented by —N (R 4 ) (R 5 ) is a substituted or unsubstituted nitrogen-containing aliphatic heterocycle. Represents a formula group or a substituted or unsubstituted amino group. Or a pharmacologically acceptable salt thereof as an active ingredient. |