http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2000053661-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24aca9ded2638ea793d05360dde7a4a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f7c7159366be37ecf8a4c595cfa235a8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-52 |
| filingDate | 1998-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50d7bdebaae76f1c642fdac4d105dd1d |
| publicationDate | 2000-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2000053661-A |
| titleOfInvention | Method for producing 3- (2-bromopropionyl) -2-oxazolidinone derivative |
| abstract | (57) [Problem] To provide a production method capable of always producing a 3- (2-bromopropionyl) -2-oxazolidinone derivative in high yield and high purity. SOLUTION: After trimethylsilylation of a 2-oxazolidinone derivative using chlorotrimethylsilane and a tertiary amine in an organic solvent, an amine hydrochloride produced as a by-product is removed, followed by reaction with 2-bromopropionyl halide. In the method for producing a 3- (2-bromopropionyl) -2-oxazolidinone derivative, (1) the ratio (m / M) of the mass m of the 2-oxazolidinone derivative to the total mass M of the derivative and the organic solvent is 0. .15 or less; (2) After the reaction with the 2-bromopropionyl halide, an alkaline aqueous solution is added to adjust the pH to 5.0 to 7.0, Subsequently, a post-treatment for separating the aqueous layer is performed. (3) After the post-treatment, the organic solvent is distilled off under reduced pressure at a temperature of 70 ° C. or less. |
| priorityDate | 1998-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.