http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2000044573-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b1c7560aa50b0da1769cd5b6f735b69 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-546 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-06 |
| filingDate | 1998-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7252d4e7a2f31f3be1987fcc5484b4d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb326525668125910d359009027f7107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0bac4d2145014ff7438512ecb720edc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83647ca62bbe082d62f300ce8caa7f35 |
| publicationDate | 2000-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2000044573-A |
| titleOfInvention | Method for producing 7-aminoacyl-cephalosporin compound |
| abstract | (57) [Summary] [Problem] Even on an industrial scale, high purity 7- A novel production method capable of obtaining an aminoacyl-cephalosporin compound in a high yield of 80% or more is provided. SOLUTION: An N-substituted vinyl represented by the formula (3) is added to an acylating agent selected from methyl chlorocarbonate, ethyl chlorocarbonate, propyl chlorocarbonate and isopropyl chlorocarbonate in acetonitrile in the presence of a base. -Α-amino acid or a salt thereof is added dropwise to obtain a mixed carboxylic anhydride, and the mixed carboxylic anhydride is reacted with the cephem compound represented by the formula (1) in the presence of an amide solvent. The method for producing a 7-aminoacyl-cephalosporin compound represented by the formula (2). Embedded image Embedded image Embedded image [Wherein R is an optionally substituted phenyl or heterocyclic group, R 6 is a lower alkyl group, R 7 is a hydrogen atom, R 8 is a lower alkyl group, X is a hydrogen atom, R 1 is a hydrogen atom, R 2 is a hydrogen atom or a carboxylic acid protecting group, R 3 is a hydrogen atom Or an amino protecting group. ] |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015518014-A |
| priorityDate | 1998-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.