| abstract |
(57) [Problem] To provide a compound showing an antagonistic action on all NK 1 , NK 2 and NK 3 receptors. A compound represented by the general formula (I), a pharmacologically acceptable salt thereof, an ester thereof or another derivative thereof: {R 1 , R 2 : a substitutable aryl group, a substitutable heteroaryl group; A: CH 2 , CO, SO 2 ; B: a single bond, alkylene; Alkenylene; D: O, S; E: alkylene, alkenylene; [Cyclic group G: substituted cycloalkene ring, substituted cycloalkane ring; cyclic group Ar: substituted aryl ring, substituted heteroaryl ring] R 3 : alkyl; n: 1-3}. |