| abstract |
(57) [PROBLEMS] To provide LEPRGRP polypeptides and polynucleotides. A LEPRGRP polypeptide comprising an amino acid sequence having at least 70% identity to the amino acid sequence of SEQ ID NO: 2, and a nucleotide having at least 70% identity to the nucleotide sequence of SEQ ID NO: 1 A LEPRGRP polynucleotide comprising the sequence. Efficacy LEPRGRP polypeptides and polynucleotides treat metabolic disorders including diabetes and obesity, eating disorders, cardiovascular disorders, CNS disorders including anxiety and depression, reproductive disorders, developmental disorders, and functional disorders or diseases including cancer. Are useful in diagnostic assays for such diseases. |