| abstract |
This invention relates to inhibitors of human immunodeficiency virus (HIV) replication with the formula N-oxides, of pharmaceutically acceptable additive salts and quaternary amines and their stereoselective chemical formulas, wherein the ring containing b1=b2- a1=a2-a3=a4 represents vinyl, pyridyl, pyrimidinyl, and pyridazinil; n = 0 to 5, m = 1 to 4 R1 hydrogen aryl, furinyl. C1-6 Alkyl Carbonyl, C1-6 Alkyloxycarbonyl, C1-6 Optionally Substituted Alkyl C3-7 Cyclo Alkyl, C2-6 Optionally Substituted Alkenyl, C1-6 Alkyloxy, C1-6 Alkyloxycarbonyl, Carboxyl, Cyano, Nitro, Amino, first or second amino (C1-6 alkyl), polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, C(=O)R6 - NH-S(=O)PR6 - S (=O)R6 and C(=NH)R6, NHC(=O)R6, C(=O)NH NH 2, NHC(=O)H, or five-membered heterocycle, X is NR5 - NH-NH, N=N, C(=O) - O, c1-4 Alkanyls, CHOH, -S- and S(=O)P, and alkanyls -X2-C1-4 or C1-4 alkanyls -X2- and R3 are NHR13 and NR13 R14 and -C(=O)-NHR13 and C(= NR13 R14, C(=O)R15, CH=N-NH-C(=O)-R16 Alkyl C1-6 Replaced, Alkyloxy C1-6 Optionally substituted C2-6 Alkenyl Replaced, Alkenyl C2-6 Replaced, Alkyl C1- 6 Substituted hydroxybutyl, alkyl C(=N-O-R8)-C1-4, R4,X-R7 R7 is a halo, hydroxy-alkyl C1-6 cycloalkyl C3-7, alkyloxy C1-6 and cyano, polyhalo-alkyl C1-6 poly Halo chloroquine C1-6 chloroxycarbonyl C1-6 alkyl carbonyl C1-6, formyl, amino, first or second alkyl C1-4 and its use as medicine and preparation processes It and the pharmaceutical compositions containing it |