| abstract |
The invention introduces a synthetic polypeptide of Formula I: I’m an amide, an ester or a salt thereof, where X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are specified here. Polypeptides are APJ receptor antagonists. The invention also relates to a method for the manufacture of the polypeptide of the invention, and its therapeutic uses such as treatment or prevention of acute heart failure (ADHF), chronic heart failure, ventricular tachycardia, atherosclerosis, hypertension, cardiovascular failure disease, cardiomyopathy, fibrosis. Heart, arrhythmias, diabetes (including gestational diabetes), obesity, peripheral artery disease, cerebrovascular accidents, temporary ischemic attacks, thumping brain injuries, amyotrophic lateral arteriosclerosis, burn injuries (including sunburn) and preeclampsia. The present invention also provides a combination of pharmacologically active agents and a pharmaceutical composition. |