| abstract |
The present invention relates to new products of formula (I): in which ---- represent a single or double bond; Ra represents a hydrogen atom; a halogen atom; an alkoxy fissure, a cycloalkyl -O; aryl mixed; X or NR1R2; X represents SO, S or SO2; A represents NH or S; W represents hydrogen atom, alkyl or COR with R represents annular alkyl; optionally substituted alkyl NR3R4, alkoxy, hydroxy, phenyl, mixed aryl or mixed alkyl The cocci fraction is optionally replaced by the NR3R4 fission, meaning O- (CH2) n-NR3R4 fissure, with the phenyl -O or fenyl-O- (CH2) n fissure, with phenyl, which is optionally substituted and n represents an integer from 1 to 4; or NR1R2 incision; R1 represents hydrogen atom or alk and R2 represents y Hydrogen, cycloalkyl or alkyl fissure; R3 and R4 represent a hydrogen atom or alk fissure, cycloalkyl, mixed aryl or phenyl; R2, R1 and / or R4, R3 together with a nitrogen atom form an optionally ring containing N, S, O and And / or NH; all mixed cycloalkylated fractions, mixed arylates, phenyls and cyclic groups are optionally substituted; such products are in any of the isomeric forms and salts, as pharmaceuticals, in particular as MET inhibitors. |