| abstract |
The present invention relates to compounds of the general formula: where R1 is pheny1, piperidinyl-yl or morpholiny1 A is –O- and R is the lowest alkyl- (CH2). nN (R ') - C (O) -1ower alkyl) - (CH2) nN (R') - C (O) -, alkyl (- (CH2) nO-1ower alkyl) - (CH2) nO, alkyl - (- (CH2) n1-O- (CH2) nO) - (CH2) 11-O- (CH2) -O- lower alky1 (lower alky1), morpholinil –n (CH2) (- (CH2) n -morpholinyl) Phenyl-n (CH2) (- (CH2) n-pyridiny1 (2 '' - - CH2) nN (R n-2 — oxo-pyrrolidinyl ((CH2) n-2-oxo-pyrrolidinyl) or circular alkyl - C4-6 (C4-6-cycloalkyl;) R ”separately hydrogen (lower alkyl) and n is 1 or 42 or A is (N (R ')) - and R is the lowest alkyl 4-6 (C4-6-cycloalkyl, (CH2) nO-lower alkyl, - (CH2) nO), pyridineyl - (CH2) n - (CH2) n-piperidinyl, piperidinyl - (CH2) n - ( CH2) n-piperidinyl ,, phenyl - (CH2) n - - (CH2) n-phenyl, alkyl - CH2 (nN (R ") - C (O) - - (C (O) - lower alky1-) CH2) nN (R ") morpholinyl - - (CH2) n- - (CH2) n-morpholinyl, or (CH2) nN (R") 2 R 'and R ”each separately hydrogen (hydrogen) or alkyl below (lower alkyl) and n is 1 or 2 or A - CH2 - is the lowest alkyl O N (R ") - (CH2m- - (N (R") - (CH2) mO-lower alkyl (S, N (R ' (2) S-lower alkyl, cetidiny1, pyrrolidinyl or piperidinyl, which is optionally substituted by hydroxyl or lower alkoxy or morpholinyl, Circular N (R ") - CH2) m-C4-6- - (N (R") - CH 2) m-C4-6-cycloalkyl,, N (R ") - (CH2m-C (O) OH- -, -2-oxo-pyrrolidine |