| abstract |
-Oxyacetylamide represented by the formula I (FORMULA I) in which R1 is chosen from (FORMULE a, b, c, d) in which: the dotted line indicates the optional bond; X and Y are chosen independently of hydrogen, halogen, cyan, hydroxy, lower alkoxy, benzyloxy, lower alkyl, nitro, amino, amino carbonyl, lower alkylamino, lower dialkylamino and lower alkanoylamino, Z is -O-, -S- or -N (R4) -; and R4 and R5 are chosen independently of hydrogen or lower alkyl or (lower cycloalkyl) -lower alkyl or are together - (CH2) n - where is n is an integer from 3 to 5; R2 is chosen from (FORMULE e, f , g, h,) wherein: p is 0 or 1; q is 1, 2, or 3 and R6 is (C1-7) -alkyl; and R3 is selected from hydrogen or lower alkyl; or their pharmaceutically acceptable salts, individual isomers or mixtures of isomers, processes for their preparation, compositions, and methods for their use. |