http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IT-1196390-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec2cf2772a722c89d7cdeaf3f7f441cc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-28 |
| filingDate | 1984-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1988-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b86f277b531c63e7bb8c81eaeadc87b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_631babe9fa692c5757c57b832b1a5974 |
| publicationDate | 1988-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IT-1196390-B |
| titleOfInvention | USE OF THIOPHENE DERIVATIVES IN THE TREATMENT OF CANCERS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND COMPOUNDS SUITABLE FOR THE PURPOSE |
| abstract | New pharmaceutical compsns. contain thiophene cpds. of formula (I) or their addn. salts, together with a diluent. R1 = H, p-nitrophenoxy, halogen, carboxy, CON(R5,R6), CONH(CHR9)nCOOH, CH2NHR8 NH(CHR4)nAR10, CH=NOH, NO2, CHO, OR7; R5, R6, R7 = H, 1-8C alkyl, thiophene, imidazole, ascorbyl peptidyl having up to 5 aminoacids or a sugar radical; or NR5R6 = 5-membd. heterocyclic ring opt. contg. additional O or N atoms; R8 = acyl of a 1-4C aliphatic carboxylic acid; R4 = H or methyl; R10 = methyl or phenyl; A = CO or SO2; n = 1,2,3 or 4; R2 = H, NO2, halogen, CH(COOH)2 OH or (CH2)mCOOH; m = 0,1,2,3 or 4; R3 = H, NO2 or OH; R4 = H, NO2, halogen, SO2CH3, OH or N(R5,R6); provided at least 2 of R1,R2,R3,R4 are not H. Cpds. (I) are new with the restrictions: R1 is not H when R2 and R4 are NO2 and R3 is H; R1 is not I when R2 is NO2, R3 is H and R4 is NO2 or CH3SO2; R1 is not p-nitrophenoxy when R2 is NO2, R3 and R4 are H; and R1 is not CONH2 or COOH when R4 is NO2, R2 and R3 are H. |
| priorityDate | 1984-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.