http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IT-1135358-B

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07G-
filingDate 1981-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1986-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9da5f4b3506bce94c076684eea8271dd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d52d9a4030e3d25ea3350168c5594212
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publicationDate 1986-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber IT-1135358-B
titleOfInvention PROCEDURE FOR REGULATING THE PRODUCTION OF ALCALOIDS IN FERMENTATION PROCESSES
abstract A process is claimed for regulating the amt. and proportions of alkaloids obtained by culturing mutant strains of Claviceps purpurea which produce principally ergocornine (Ia), alpha- ergocryptine (Ib) and beta-ergocryptine (Ic). The process comprises using a cpd. which acts as a precursor for isoleucine biosynthesis, or which stimulates isoleucine formation by biochemical control, as a regulator during conventional fermentation. The regulator can be methyloxalacetic acid, alpha-ketobutyric acid, threonine, homoserine, homocysteine and/or methionine. It can be used in an amt. of 0.01-10 (pref. 0.05-5.0) g/l. The proportions of (Ic) can be increased to the level required for prodn. of dihydroergotoxine, which is used as the (m)ethanesulphonate for treatment of peripheral and cerebral circulatory disorders.
priorityDate 1981-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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