http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IT-1132531-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_60fb4ee2536392115237a4ac22f8d7ff |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate | 1980-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1986-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e38e0a6ed1482127570d404f352f2bcd |
| publicationDate | 1986-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IT-1132531-B |
| titleOfInvention | IMMINO-ALCHILE AND AMINO-NITRILE CIAN-GUANDINE |
| abstract | N-Cyano-guanidines of formula (I), which exist in the tautomeric form, amino-methyl and imino-nitrile, and as the geometric isomer which is different from the tautomeric form and isomer of the same general formula, which is already known. In (I) (a) R1 is H and R2 is 2-mercapto-ethyl (Cpd.A); (b) R1 is H and R2 is 2-(4-methyl-5-imidazolyl-methylthio)-ethyl (Cpd.B), and (c) R1 and R2 together are -CH2-CH2-, i.e. together with the N atom form an aziridine ring (Cpd.C). The new isomeric form is the syn-(-NHCH3) form. The syn(-NHCH3) form Cpd. B is a histamine H2 receptor antagonist, which reduces gastric secretion, and is used in the treatment of gastric and duodenal ulcers. The syn isomer of the present invention has better bio-availability and better-aqueous solubility than the known-anti isomer (cimetidine). |
| priorityDate | 1980-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 19.