http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IT-1117947-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96c62cca70715f5945bde1051ddc2810 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate | 1977-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1986-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1986-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IT-1117947-B |
| titleOfInvention | DERIVATIVES OF 2H, 3H-BENZIMIDAZO (1,2-B) OSSAZOLE EQUIPPED WITH ACTION ON THE CENTRAL NERVOUS SYSTEM AND ANTIRE SERPINIC ACTION, AND RELATED PHARMACEUTICAL COMPOSITIONS |
| abstract | 2H, 3H-benzimidazo(1,2-b)oxazole derivs. of formula (I) can be used to treat the CNS (where R is 1-4C alkyl, CH2Cl, CH2OH, COOR', CONHR2, CH2NHR2, CH2NR3R4, CH2OAr or CH2OCOCH3; R1 is H, 1-4C alkyl or the equiv. of an alkali or alkaline earth metal; R2 is H, 1-4C alkyl or opt. substd. benzoyl; R3 and R4 together with the N atom to which they are attached from phthalimido or a 5 or 6 membered ring opt. contg. other heteroatoms; and Ar is opt. substd. Ph). (I) are new, except those in which R = Et, CH2Cl or CH2OH. (I) are CNS depressants and have an antireserpin activity e.g. (I; R = N-morpholino methyl) in a dose of 45 mg/kg i.p. doubles the duration of Pentobarbital induced narcosis in mice (50 mg/kg Pentobarbital); 55 mg/kg i.p. reduces the spontaneous motility by 50%; 200 mg/kg completely inhibit reserpin induced prosis in mice 60 min. after administration. (I) are of low toxicity e.g. (I; R = N-morpholinomethyl) has Ld50 iv. mice of 147.5 mg/kg. (I) can be used therapeutically esp. to treat disorders of the general and peripheral nervous system e.g. to treat psychomotoric stimulation, insomnia and depressive conditions. A specifically claimed cpd. is 2-(N-morpholino-methyl)-2H, 3H-benzimidazo (1,2-b) oxazole. |
| priorityDate | 1977-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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