http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IT-1111474-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_413699f78692c85cc58872be1853cfc3 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- |
| filingDate | 1978-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1986-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fe26b4810dc9ecfb4aeb175be9eaa39 |
| publicationDate | 1986-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IT-1111474-B |
| titleOfInvention | 6 CYCLOPROPYL 1 OR DIHYDRO I METHYL 5 FENYL 2 BONE 2H HOLD 2 3 AND DIAZEPIN PROCEDURE FOR ITS PREPARATION AND THERAPEUTIC APPLICATION |
| abstract | The thieno-diazepin deriv. of formula (I) and its pharmaceutically acceptable acid addition salts, specifically the hydrochloride, are new:- (I) is prepd. by first reacting cyclopropyl methyl ketone with benzoylacetonitrile; sepg. the cis isomer of the prod. and reacting in sequence with S, BrCH2COBr anf NH3. The prod. is then cyclised to the 1-4-analogue of (I) which is methylated. (I) is used to treat gastroduodenal disorders, specifically to protect against ulcers. It is pref. administered orally at 0.1-0.3g/day. It has oral LD50 in rats of 915mg/kg with a therapeutic index of 23. |
| priorityDate | 1978-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 18.