| abstract |
5-(Difluoromethyl)pyrazine-2-carboxilic acid, which is a raw material for the construction of 5- (difluoromethyl)pyrazine-2-carboxamide, which is a common partial structural motif of the compound having an A production in hibitory action or a BACE1 inhibitory action, can be industrially advantageously produced by decarboxylating 5- [carboxy(difluoro)methyl]pyrazine-2-carboxylic acid, which is obtainable from 5-chloropyrazine-2-carboxylate. |