http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IN-2014DN06939-A

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publicationDate 2015-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber IN-2014DN06939-A
abstract Provided is a sustained release oral solid preparation comprising aripiprazole or a salt thereof as an active ingredient described below and a method for producing the sustained release oral solid preparation. A sustained release oral solid preparation comprising aripiprazole or a salt thereof and a sustained release excipient the sustained release excipient comprising a gelling agent; at least one inert pharmaceutical diluent selected from the group consisting of monosaccharides disaccharides polyhydric alcohols and mixtures thereof; and a pharmaceutically acceptable cationic cross linking agent capable of crosslinking with the gelling agent and increasing the gel strength when the sustained release oral solid preparation is exposed to an environmental fluid the gelling agent comprising xanthan gum and locust bean gum the ratio of the xanthan gum to the locust bean gum in the gelling agent being about 1:1 to 1:3 by weight the ratio of the inert pharmaceutical diluent to the gelling agent being about 1:1 to 1:2 by weight.
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