| abstract |
A compound of general formula (I) wherein: R1 and R2 represent, independently of each other, an optionally substituted C, C10 aryl radical or an optionally substituted hotoroaryl radical; A and M represent, independently of each other, a methylene group or a single bond, in which case the adjacent aromatic ring would be attached directly to the amide group; the Y=Z group represents together and indistinctly an oxygen atom, a sulfur atom ( S), a cis-vinylidene group an imino group or a methine group with a sp^-hybridized carbon atom X represents indistinctly a methine group, a cis vinylidcne groi.i CH=CH-) or a nitrogen atom and W represents a hydroxyl group , an optionally substituted C1 C6 alkyl, group, an optionally substituted heteroaryl group or an optionally substituted C1 C10 aryl group; or a salt, solvate or prodrug thereof, as well as to the process for their preparation and the use thereof for the treatment of cancer. |