http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IL-44815-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2dbb2d7ecbd600cf89fbdd230f4a466c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-24 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 |
| filingDate | 1974-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IL-44815-A |
| titleOfInvention | 3-(piperazin-1-yl) carbonyloxy (naphthyridin-2-yl) isoindolinones pyrrolo (3,4-b) pyrazines and pyrrolo (3,4-b) pyridines processes for the preparation thereof and pharmaceutical compositions containing the same |
| abstract | 1417935 Naphthyridine derivatives RHONEPOULENC SA 13 May 1974 [15 May 1973 14 March 1974 (2)] 21081/74 Heading C2C Novel compounds I (in which one symbol X is =N-and the others are all -CY=; Y is H, halo, 1-4 C alkyl or alkoxy, CN or NO 2 ; A is =CH- and A 1 is =CH- or =N- or A is =N- and A 1 is =N-; Z is H, halo, 1-4 C alkyl or alkoxy or NO 2 ; m is 0 or 1-4; and (i) n is O or R is H, 1-4 C alkyl, 2-4 C alkenyl or alkynyl, 1-4 C hydroxyalkyl or phenyl or (ii) n is 1 and R is 1-4 C alkyl or hydroxyalkyl or phenyl) and acid addition salts thereof are prepared by (i) reaction of a piperazine II with a naphthyridine III or an alkali metal derivative thereof; (ii) reaction of a piperazine VIII with a mixed carbonate IX (in which Ar is phenyl which may be substituted by 1-4 C alkyl or NO 2 ) or (iii) oxidation of a compound I in which n is 0 to give a compound in which n is 1. Compounds III may be prepared by reaction of a compound V with a compound VI to give a compound VII cyclization of the compound VII to give an imide IV which is then partially reduced. Compounds VIII in which n is 1 may be prepared by oxidation of those in which n is 0. Compounds IX may be prepared by reaction of a chloroformate CICOOAr with a compound III. 2 - Amino - 7 - methoxy - 1,8 - naphthyridine is prepared by reaction of sodium methoxide with 2 - acetamido - 7 - chloro - 1,8 - naphthyridine. Pharmaceutical compositions useful as anticonvulsants and tranquillizers comprise a compound I or a suitable salt thereof in combination with a carrier or diluent.n[GB1417935A] |
| priorityDate | 1973-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 183.