| abstract |
2-Amino-4 H-pyrane derivatives of the formula WHEREIN R1 and R2 are the same or different and each is hydrogen or straight- or branched-chain alkyl; R3 is straight- or branched-chain alkyl, phenyl or -COOR' wherein R' is a straight, branched or cyclic saturated or unsaturated aliphatic hydrocarbon; R4 is straight, branched or cyclic alkyl or alkenyl, aryl unsubstituted or substituted by 1, 2 or 3 of the same or different substituents selected from the group consisting of alkyl, alkoxy, halogen, nitro, cyano, trifluoromethyl, carbalkoxy, and -SOn alkyl wherein n is 0, 1 or 2, or R4 is naphthyl, quinolyl, pyridyl, thenyl or furyl unsubstituted or substituted by alkyl, alkoxy or halogen; R5 is straight, branched or cyclic alkyl or -OR'' wherein R'' is a straight, branched or cyclic hydrocarbon or said hydrocarbon interrupted by 1 or 2 oxygen atoms; and R6 is hydrogen or alkyl; ARE USEFUL FOR THEIR STRONG CORONARY ACTION AND AS ANTIHYPERTENSIVE AGENTS.n[US3897462A] |