| abstract |
Substituted analgenic cycloheptenes of the formula in which R1 represents OH, O-(C1-C6)-alkyl, O-(C3-C7)-cycloalkyl, O-aryl, C1-C6-alkyl-COO-, aryl-COO-, R2 represents C1-C6-alkyl, (CH2)(1-2)-aryl, C2-C6-alkenyl-aryl and R3 represents (CH2)(0-1)-C5-C7-cycloalkyl, -(CH2)(0-2)-aryl, heterocyclyl, C1-C6-alkyl-heterocyclyl, or their enantiomers, diastereomers, racemates, bases or salts of physiologically acceptable acids, and wherein the term " aryl" denotes naphthyl, or phenyls which are unsubstituted or mono or polysubstituted by OH, F, Cl, CF3, C1-6-alkyl, C1-6-alkoxy, C1-7-cycloalkoxy, C3-7-cycloalkyl, C2-6-alkenylene, heterocyclyl or phenyl and the term " heterocyclyl" denotes 5- or 6-membered saturated or unsaturated heterocyclic compounds which are optionally provided with a fused-on aryl system and contain 1 or 2 heteroatoms from the group consisting of nitrogen, oxygen and/or sulfur. |