http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IL-121599-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f7ddc4774cf5f8a0bda44a780d73c53d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 |
| filingDate | 1997-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2004-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IL-121599-A |
| titleOfInvention | Process for making paclitaxel |
| abstract | A process for preparing paclitaxel of the formula 1315 א' בתמוז התשס" ד - June 20, 2004 characterized in that (a) an oxazolidine derivative of the formula or its salt, in which X represents halogen, is coupled with a 7-trihaloacetyl-baccatin III of the formula in which R1 represents trihaloacetyl, in a solvent in the presence of a condensing agent to produce an oxazolidine substituent-containing taxane of the formula in which X and R1 are each as previously defined; (b) the oxazolidine ring is opened in a solvent in the presence of an acid, and the product thus obtained is reacted with benzoyl chloride in the presence of a base to produce a protected paclitaxel wherein the hyroxy group at 7-position is protected with trihaloacetyl group of the formula 1316 א' בתמוז התשס" ד - June 20, 2004 in which R1 is as previously defined; (c) then the protecting group at the 7-position is removed by ammonia or a salt of ammonia with a weak acid in a solvent. Claimed as novel is the intermediate of the formula |
| priorityDate | 1996-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 171.