http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IL-121358-A
Outgoing Links
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|---|---|
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| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-425 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C251-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-197 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-04 |
| filingDate | 1997-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IL-121358-A |
| titleOfInvention | New imino histories that act as inhibitors of bone resorption and are antagonists of vitronectin receptors, the process for their preparation and the pharmaceutical preparations containing them |
| abstract | Compounds of the formula R1-Y-A-B-D-E-F-G in which: A is a direct bond, (C1-C8) - alkanediyl, -NR2-N=CR2-, -NR2-C(O)-NR2-, -NR2-C(O)O-, -NR2-C(O)S-, -NR2-C(S) -NR2-, -NR2-C(S)-O-, -NR2-C(S)-S-, -NR2-S(O)n-NR2-, NR2-S(O)n-O-, -NR2-S(O)n-(C3-C12)- cycloalkanediyl, -C:C-, -NR2-C(O)-, -C(O)-NR2-, -(C5-C14)-arylene-C(O)-NR2-, -O-, -S(O)n-, -(C5-C14)-arylene-, -CO-, (C5-C14)-arylene-CO-, NR2-, -SO2-NR2-, -CO2-, -N=CR2-, -R2C=N-, -CR2=CR3-, -(C5-C14)-arylene- S(O)n-, which can in each case be mono-or disubstituted by (C1-C8) - alkanediyl-, B is a direct bond, (C1-C8)-alkanediyl, -CR2=CR3- or -C:C-, which in each case 1329 כ" ג בסיון התשס" א - June 14, 2001 can be mono- or disubstituted by (C1-C8)-alkanediyl, or a divalent radical of a 5- or 6-membered saturated or unsaturated ring, which can contain 1 or 2 nitrogen atoms and can be mono- or disubstituted by (C1-C6)-alkyl or doubly bonded oxygen or sulfur; D is a direct bond, (C1-C8)-alkanediyl or -O-, -NR2-, -CO-NR2-, -NR2-CO-, -NR2-C(O)-NR2-, -NR2-C(S) -NR2-, -OC(O)-, -C(O)O-, -CO-, -CS-, -S(O)-, -S(O)2-, -S(O)2-NR2-, -NR2-S(O)-, -NR2-S(O)2-, -S-, -CR2=CR3, -C:C-, -NR2-N=CR2-, -N=CR2-, -R2C=N-or -CH(OH)-, which in each case can be mono-or disubstituted by (C1-C8) - alkanediyl; E is a 6-membered aromatic ring system, which optionally contains up to 4 nitrogen atoms and is optionally substituted by 1-4 identical or different radicals from the group consisting of R2, R3, fluorine, Cl, Br, I, NO2 and OH; F is defined as D; G is Y is a direct bond or -NR2-; R1 is R2-C(=NR2)-NR2-, R2R3N-C(=NR2)-, R2R3N-C(=NR2)-, or a 4-10-membered mono-or polycyclic aromatic or nonaromatic ring system, which can optionally contain 1-4 heteroatoms from the group consisting of N, O and S and can optionally be monosubstituted or polysubstituted by substituents from the group consisting of R12, R13, R14 and R15; R10 is C(O)R11, C(S)R11, S(O)nR11, P(O)(R11)n or a four-to eight- membered, saturated or unsaturated heterocycle which contains 1, 2, 3 or 4 heteroatoms from the group N, O, S, R4, R5, R6, R7, R11, R12, R13, R14, R15, are as defined in the specification, n is 1 or 2; p, q independently of one another are 0 or 1; in all their stereoisomeric forms and mixtures thereof in any ratio; and their physiologically tolerable salts; where in the compound of the formula I at least 1 of the groups A, D or F is -NR2 -N=CR2-, -N=CR2- or -R2C=N-. |
| priorityDate | 1996-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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