| abstract |
A 1, 2, 3, 4-tetrahydro- 2-naphthalenamine bearing a phenyl substituent on the aromatic ring, in free base or acid addition salt form, for use in the treatment of epilepsy, stroke and brain or spinal trauma. Claimed as novel are the compounds of the formula wherein R1 and R2, independently, are hydrogen, (C1-C4) alkyl, (C1-C4) alkoxy, (C1-C4) alkylthio, halogen, trifluoromethyl, trifluoromethoxy, cyano, (C2-5) alkanoyl, (C1-4) alkylsulfonyl or sulfamoyl, R3 is hydrogen, hydroxy, (C1-4) alkyl, (C1-4) alkoxy, halogen, cyano, (C2-5) alkanoyl, carbamoyl, (C1-4) alkylsulfonyloxy or trifluoromethylsulfonyloxy, and R4 and R5, independently, are hydrogen, (C1-C4) alkyl, hydroxyl (C2-4) alkyl or phenyl (C1-4) alkyl, or form together with the nitrogen atom to which they are attached a pyrrolidinyl, piperidino or piperazinyl group, in free base or acid addition salt form. 3123 ה' בכסלו התשס" ג - November 10, 2002 |