| abstract |
Tachyikinin-antagonistic compounds of the formula wherein G1 is -CH2- or -C(O)-; G2 is -CH2- or -C(O)-; G3 is -CH2- or -C(O)-; m is 0 or 1; Ar1 is a radical chosen from the group: 2132 כ" ה באלול התשס" א - September 13, 2001 wherein Z1 is from 1 to 3 substituents each independently chosen from the group consisting of hydrogen, halogen, benzyloxy, hydroxy, CF3, C1-C4 alkyl, and C1-C4 alkoxy; Ar2 is a radical chosen from the group wherein Z2 is from 1 to 3 substituents each independently chosen from the group consisting of hydrogen, halogen, benzyloxy, hydroxy, CF3, C1-C4 alkyl, and C1-C4 alkoxy; Ar3 is a radical chosen from the group wherein Z3 is from 1 to 3 substituents each independently chosen from the group consisting of hydrogen, halogen, benzyloxy, hydroxy, CF3,C1-C4 alkyl, and C1-C4 alkoxy; R6 is hydrogen, C1-C4 alkyl, or -CHO; R1 is hydrogen, C1-C4 alkyl, -(CH2)qAr4, or -CH2C(O)Ar4 wherein q is an integer from 1 to 4 and Ar4 is a radical of the formula 2133 כ" ה באלול התשס" א - September 13, 2001 wherein Z4 is from 1 to 3 substituents each independently chosen from the group consisting of hydrogen, halogen, benzyloxy, hydroxy, CF3, C1-C4 alkyl, and C1-C4 alkoxy; or stereoisomers, or pharmaceutically acceptable salts thereof; with the proviso that, when G1 is -C(O)-, then G2 is not -C(O)-; and with the further proviso that, when G3 is -CH2-, then G1 and G2 are -CH2-. |