http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IL-116504-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56 |
| filingDate | 1995-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IL-116504-A |
| titleOfInvention | Steroids are mediated by C2 at positions 14, 17 and pharmaceutical preparations containing them |
| abstract | 14, 17-C2-Bridged steroids of the formula in which R3 stands for an oxygen atom, the hydroxyimino group or two hydrogen atoms, R6 stands for a hydrogen, fluorine, chlorine or bromine atom or for a C1-C4 alkyl radical in a-or b-position, and then R6 and R7 represent hydrogen atoms or else R6 stands for a hydrogen, fluorine, chlorine or bromine atom or for a C1-C4 alkyl radical, and then R6' and R7 represent a common additional bond, R7 stands for a C1-C4 alkyl radical in a- or 2946 י' בכסלו התשס" ב - November 25, 2001 b-position, and then R6 and R6' represent hydrogen atoms, or else R6 and R7 together stand for a methylene group in a- or b-position and R6 stands for a hydrogen atom or R6 and R6' together stand for an ethylene or methylene group and R7 stands for a hydrogen atom, R9 and R10 each stand for a hydrogen atom or a common bond, R11 and R12 each stand for a hydrogen atom or a common bond, R13 stands for a methyl or ethyl group, R15 stands for a hydrogen atom or a C1-C3 alkyl radical, R16 and R16' independently of one another, stand for a hydrogen atom, a C1-C3 alkyl radical or a C2-C4 alkenyl radical or together for a C1-C3 alkylidene group, R15 and R16 stand for a common bond and R16' stands for a hydrogen atom or a C1-C3 alkyl radical or R14 and R16 together stand for a ring of partial formula in which n = 1 and 2 and X means a methylene group or an oxygen atom, and R16' stands for a hydrogen atom, R171 stands for a hydrogen atom or a C1-C3 alkyl radical, R172 stands for a hydrogen atom, a C1-C3 alkyl radical or a C2-C4 alkenyl radical, R171' and R172' each stand for a hydrogen atom or for a common bond, R21 stands for a hydrogen atom or a C1-C3 alkyl radical, R21' stands for a hydrogen atom, a C1-C3 alkyl radical or a hydroxy group, except for the compound 14, 17-ethano- 19-norpregn-4-ene-3,20-dione. Also claimed are intermediate products of the formula II, III, IV, V and VI as defined below R13 = -C2H5; R21 = hydrogen, C1-C3 alkyl or R13=-CH3; R21 = C1-C3 alkyl and R171 and R172 = independently of one another, hydrogen or C1-C3 alkyl, R171' and R172' = in each case hydrogen or together a bond; 2947 י' בכסלו התשס" ב - November 25, 2001 in which R13=-CH3, -C2H5, R171 and R172 = independently of one another, hydrogen or C1-C3 alkyl, R171' and R172' = in each case hydrogen or together a bond, K = a ketal protective group, R21 = hydrogen, C1-C3 alkyl; in which R13 = CH3, -C2H5, R16 = COOalkyl, in which alkyl is a C1-C4 alkyl radical, or -CH2OH or CHO, or methylene, R171 and R172 = independently of one another, hydrogen or C1-C3 alkyl, R171' and R172' = in each case hydrogen or together a bond, K = an oxygen atom or ketal protective group, R21 = hydrogen, C1-C3 alkyl; 2948 י' בכסלו התשס" ב - November 25, 2001 in which R13 = -CH3, -C2H5, R15 and R16 = together a ring of partial formulae in which X and Y = independently of one another, in each case an oxygen atom or two hydrogen atoms and Rm = C1-C3 alkyl or R15 and R16 = each per se for an -OH group or R15 and R16 = together a bond and R171 and R172 = independently of one another, hydrogen or C1-C3 alkyl, R171' and R172' = in each case hydrogen or together a bond, K = an oxygen atom or a ketal protective group, R21 = hydrogen or C1=C3 alkyl; 2949 י' בכסלו התשס" ב - November 25, 2001 in which R13 = CH3, -C2H5, R15 and R16 = in each case hydrogen or together a bond, R15( = hydrogen or C1-C3 alkyl, R16( = -COO alkyl, in which alkyl is a C1-C4 alkyl radical, or CH2OH or CHO or a C1-C3 alkyl radical, R171 and R172 = independently of one another, hydrogen or C1-C3 alkyl, R171' and R172' = in each case hydrogen or together a bond, K = an oxygen atom or a ketal protective group, R21 = hydrogen or C1-C3 alkyl. The compounds of the formula (I) have gestogen activity. |
| priorityDate | 1994-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 132.