| abstract |
A compound of the formula glycosyl-Y[--C(=Y)--X--]p --W(R)n --X- -C(=Y)--drug in which glycosyl is a poly-, oligo- or monosaccharide which can be cleaved off enzymatically; W is an aromatic or heteroaromatic or aliphatic group with conjugated double bonds or an amino-acid derivative which cyclizes after elimination of the glycosyl radical in which the substituents; R are, independently or identically, H, methyl, methoxy, carboxyl, methyloxycarbonyl, CN, hydroxyl, nitro, fluorine, chlorine, bromine, sulfo, sulfamoyl or (C1-4) - alkylsulfamoyl and p is 0 or 1, n is an integer, X is O, NH, methyleneoxy, methyleneamino or methylene (C1-4) - alkylamino and Y is O or NH, and drug is a compound which is linked via a hydroxyl, amino or imino group and has a biological effect, except anthracyclines linked via a 3'-amino group when p=0. 2312 ד' בשבט התשס" א - January 28, 2001 |