http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IL-100430-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7b4beef0c137d9094e6918ee382be22f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-335 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 |
| filingDate | 1991-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1997-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IL-100430-A |
| titleOfInvention | Pharmaceutical compositions containing 2-phenyl- (ethyl or propyl)-2- (imidazol-1-yl) methyl-4- (phenylthio or phenoxy) methyl-1,3-dioxolane derivatives, certain such novel compounds and their preparation |
| abstract | Use of a compound of the formula OOX (R2)qR3 (R1)p(CH2)n CH2 - NNR4 (I) wherein n is 2 or 3; p is 0, 1 or 2; q is 0, 1 or 2; X is oxygen or S(O)t where t is 0, 1 or 2; each R1 is independently halo, lower alkyl, lower alkoxy, or trifluoromethyl; each R2 is independently halo or lower alkyl; R3 in nitro or -N(R5)R6 where R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylsulfonyl or -C(Y)R7 where Y is oxygen or sulfur and R7 is hydrogen, lower alkyl, lower alkoxy or -N(R8) R9 where R8 is hydrogen or lower alkyl and R9 is hydrogen, lower alkyl or lower alkoxycarbonyl; or R5 and R6 together with N is pyrrolidino, piperidino, morpholino, thiomorpholino or piperazino, wherein the piperazino is optionally substituted at the 4-position by -C(O)R10 where R10 is hydrogen, lower alkyl, lower alkoxy or amino; and R4 is hydrogen or lower alkyl, as a single stereoisomer or as a mixture thereof; or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament against disease-state characterized by hypercholesterolemia, substantially as described in the specification. The compounds of formula (I) are claimed as novel with the proviso that when X is oxygen, R7 cannot be lower alkoxy and R5 and R6 together with N cannot be pyrrolidino or piperidino. |
| priorityDate | 1990-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.