http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-920840-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6f5033fcf56d5a13743728cc85a8dc3f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-00 |
| filingDate | 1992-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa304f0c972e085791bcaa2a856b1750 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a1e6324454f39cec4688723342898ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0c93dff7fb4db2ce8062fd5bcf5d8be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5db4468216618c53ca09300b0db57518 |
| publicationDate | 1992-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-920840-A1 |
| titleOfInvention | Alkylenedioxyphenyl ether derivatives having anti-ischaemic,¹memory enhancing and anti-convulsive activity |
| abstract | The invention relates to compounds having anti-ischaemic activity, memory enhancing activity and anti-convulsive activity of the formulae 1 A and 1 B wherein -R, + R2 together form an alkylene group having 1-3 C-atoms which may be substituted with one or more alkyl group(s) having 1- 3 C-atoms; -Z is methylene optionally substituted with one alkyl group having 1-3 C-atoms, or with one phenylalkyl group with 1-3 C-atoms in the alkyl group, which phenyl group may be substituted with a group (Re)p wherein Re is halogen, hydroxy, alkyl or hydroxyalkyl having 1-5 C-atoms, alkoxy having 1-3 C-atoms, S-alkyl, S(O)-alkyl or S(O)2-alkyl having 1-3 Catoms, amino, mono- or dialkylamino having 1-3 C-atoms per alkyl group, trifluoromethyl, trifluoromethoxy, a sulphonylamido group SO2NHR or a carbalkoxy group COOR wherein R is alkyl having 1-4 C-atoms, the group COOH, SO3H,CONH2, the amidino group or cyano group, and p has the value 0-3; -R3 and R4 independent of each other represent hydrogen, alkyl having 1-10 C-atoms, alkenyl or alkynyl having 3-10 Catoms, cycloalkyl having 3-8 C-atoms, cycloalkyl-alkyl having 3-8 ring atoms and 1-5 C-atoms in the alkyl group, phenylalkyl or heteroaryl-alkyl having 1-5 C-atoms in the alkyl group, phenylalkenyl, heteroaryl-alkenyl, phenylalkynyl or heteroaryl-alkynyl group having 3-5 C-atoms in the alkenyl group or alkynyl group, which groups R3 and R4 may be substituted with a group (Re)p wherein Re and p have the above mentioned meanings, or wherein R3+R4 together wthe nitrogen atom form a saturated or unsaturated heterocyclic group of 5-7 ring atoms, which may contain a second hetero-atom from the group consisting of oxygen, sulphur and nitrogen, which ring may be substituted with a 5 group (R6)p wherein R6 and p have the above mentioned meanings, or with phenylalkyl, heteroarylalkyl.phenylalkenyl, heteroaryl-alkenyl, phenylalkynyl or heteroaryl-alkynyl having at most 3 C-atoms in the alkyl, alkenyl or alkynyl part, which groups may ba substituted with a group (Re)p wherein R6 and 10 p have the above-mentioned meanings, or which ring may be annelated with a phenyl group; -R5 is alkyl having 1-12 C-atoms, alkenyl or alkynyl having 3-12 C-atoms, cycloalkyl having 3-8 C-atoms, cycloalkyl-alkyl having 3-8 ring atoms and 1-5 C-atoms in the alkyl group, 15 phenylalkyl or heteroaryl-alkyl having 1-5 C-atoms in the alkyl sub-group, phenylalkenyl, heteroaryl-alkenyl, phenylalkynyl or heteroaryl-alkynyl having 3-5 C-atoms in the alkenyl subgroup or alkynyl sub-group, which groups may be substituted with a group (Re)p, wherein Re and p have the above- 20 mentioned meanings, and which alkyl sub-groups, alkenyl sub-groups and alkynyl sub-groups may contain a group -0-, - - S- or CO, or a pharmacologically acceptable salt thereof. |
| priorityDate | 1992-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 68.